Off-Label Searching

Tutorials on how to use Off-Label.com Search the Sample Database Sample Target Library Sample Combinatorial Library and First Use Area Target Library Combinatorial Library and First Use Area Specialty Pharma

About Off-label.com
Off-label.com provides biopharma with a low cost/low risk route to product development. Since launch in 2005 Off-Label.com has now screened 5.5 million Medline citations.
Specialty Pharma Area/Using www.off-label.com
Freely available to all website visitors. Learn why www.off-label.com is a new model for R&D. Click here for details
Off-Label and Pharmacogenetics
For many patients off-label prescribing represents an attempt to fulfil unmet clinical needs. When unmet needs represent variability in response then often such differences may in part be explained by genetic polymorphism (ie pharmacogenetics). Off-label reports added to the database that define or allude to the existence of responding (or nonresponding) patient subgroups are identified in the Off-label.com citation by the descriptor SUBPOP. These citations can be identified by using the keyword SUBPOP.
Off-Label ADR Alert
Occasionally, published reports of off-label use are dedicated to reporting, or make special mention of the appearance of significant and possibly remarkable toxicity associated with the unlicensed use of a licensed drug. When such reports become known to us, relevant citations within off-label.com are annotated using the descriptor ALERT. These citations can be identified using the keyword ALERT.

1000's of novel and unexpected applications of existing drugs providing an endless supply of opportunities for creating new products with low risk and low cost.

CambridgeSoft and Off-Label Ltd Announce Co-Marketing Alliance

OFF-LABEL CORE DATABASE
A catalogue of discovery driven by clinical intuition, hypothesis and serendipity. From January 1st 2008 reports of proposed, in-progress and recently-completed clinical trials of unlicensed uses are included.

TARGET LIBRARY
Search by preclinical hit and explore the relationships between druggable targets and clinical outcomes. Discover off-target effects and hidden phenoptypes. Together, the Target Library and Core Database unite drug and target promiscuity with clinical divergence, enabling a systematic approach for designing new chemical entities. For more details click here.

FIRST REPORTS OF OFF-LABEL USE

SCREEN HITS FOR CLINICAL USES

Use the Off-label.com Target Library to translate preclinical hits into potential clinical applications.

To view a list of all human
genome-derived druggable targets available for searching, contact sales@off-label.com

Pergolide for nocturia
Citalopram for hearing loss
Cyanocobalamin for eczema
Doxycycline for Alzheimer’s
Doxycycline for restenosis
Methylphenidate for obesity
D-cycloserine for autistic disorder
Bleomycin for nose bleeds
Valproate for cognitive impairment
And so many more……….

NOVEL COMBINATIONS

Pentoxifylline plus ciprofloxacin to prevent chemoradiotherapy toxicity
Cyproheptadine plus haloperidol for autistic disorder
Disulfiram plus zinc for metastatic melanoma
Phenytoin plus vinorelbine for refractory carcinomas
And so many more…….